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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Hsieh M.J., Lee C.H., Chueh H.Y., Chang G.J., Huang H.Y., Lin Y., Pang J.S

Key metrics to track: Time to fall asleep (sleep latency) Number of nighttime awakenings Deep sleep percentage (if using a wearable) Morning alertness and energy Daytime cognitive performance Stress and cortisol management DSIP's effects on the HPA axis and cortisol regulation suggest potential benefits for stress-related sleep problems

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Agomelatine (activity at the serotonin-2C receptor) functions as an anti-depressant, ramelteon (selective MT1/MT2 agonist) is marketed for use in sleep onset insomnia, tasimelteon (MT1/MT2 agonist), is commercialized for the treatment of circadian rhythm disorders particularly non-24h sleep wake disorder (113, 114)

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How Progerin Affects Skin Aging Snippet: Progerin disrupts fibroblast activity, leading to slower collagen production, reduced repair, and visible wrinkling