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Notably, BACH1 is traditionally recognized as an angiogenesis inhibitor that regulates HO-1 or VEGF transcription

however, it was not judged to be clinically relevant

In fact, vitamin C is frequently added to many skin care products that purport to treat it

Molecules 23:309 Kim D, Hahn JS (2013) Roles of the Yap1 transcription factor and antioxidants in Saccharomyces cerevisiae s tolerance to furfural and 5-hydroxymethylfurfural, which function as thiol-reactive electrophiles generating oxidative stress

Every claim in a listed Orange Book patent has been, at least nominally, reviewed by FDA for listing eligibility

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