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Seven reported relief lasting over six months

But they also make the molecule sensitive to how it is handled during reconstitution

Pramlintide, the first human amylin analogue to receive regulatory approval, was designed, among other design features, using a triple substitution to introduce proline residues at positions 25, 28, and 29 (as in rat amylin) to avoid fibrillation

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There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions