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In vivo, phenol-rich EVOO inhibited inflammation, oxidative stress, and apoptosis, protecting against intestinal damage caused by necrotising enterocolitis [258]

These changes create self-reinforcing pathological cycles that worsen tissue function and promote systemic insulin resistance ( AT comprises distinct depots (white, brown, beige, and pink) with unique physiological functions and metabolic characteristics ( At the molecular level, adipose dysfunction involves cellular stress responses, aberrant inflammatory signaling, and dysregulated microRNA networks

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The activity assay of HDT was determined according to the previous report (Chiang et al., 2014)

8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-hydroxy-2-deoxyguanosine (8-OHdG) as a cause of autoimmune thyroid diseases (AITD) during pregnancy

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