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Furthermore, they highlighted the need for studies evaluating antioxidant supplementation in welltrained individuals and employing effective and trustworthy testing protocols [45]

TGF- is a major fibrogenic cytokine, acting as a paracrine and autocrine (from HSCs) mediator as already noted

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[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Knez W.L., Coombes J.S., Jenkins D.G

Lossoffunction MC1R variants suppress G proteincoupled receptor coupling or cell surface expression leading to a decrease in adenyl cyclase activation and intracellular levels of cyclic adenosine monophosphate