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The stemness of these BCSCs increases from ALDH + to CD24-CD44 + to those harboring both, as only 20 BCSCs expressing both CD24-CD44 + and ALDH + effectively generated tumors whereas 100 CD24-CD44 + BCSCs and 500 ALDH + BCSCs were needed, respectively, to produce the bulk tumor cells [62, 63]

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Fucoidan significantly inhibited depressive-like behavior and reduced BDNF mRNA expression in the hippocampus