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[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Kl M, Dedeolu , Gmen R, Kesici S, Yksel D: Successful treatment of a patient with ethylmalonic encephalopathy by intravenous N-acetylcysteine

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Table 1 Animal studies and clinical trials using probiotics and prebiotics in several cardiovascular diseases as a therapeutic approach

TMA-containing compound assay Trimethylamine-containing compounds were extracted from 50 l of plasma, 50 l of whole liver homogenate or from 100 l of whole brain homogenate (without the cerebellum and olfactory bulbs) by adding 10 volumes of ACN and spiking the samples with 5 l of IS mix containing 12 M d9-TMAO (CIL), 649 nM d9-TMA (CDN Isotopes), 6 M d3-L-carnitine (CIL), 329 nM d9-crotonobetaine (see Koeth et al., 2014) and 5 M d9-TML (Santa Cruz Biotechnology) at the beginning of the extraction

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