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Although CBT has shown considerable promise, its long-term effectiveness can be influenced by factors, such as treatment adherence, patient motivation, and the availability of resources for prolonged interventions ( In addition to behavioral therapies, pharmacological approaches have demonstrated potential benefits
There exist mammalian homologues of Sir2 that are SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7 (97, 134, 255, 333, 556)
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doi: 10.1097/01.psy.0000116249.60477.e9
