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W., Cheong J

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In support of the NRF2 pathway being a potential target for the treatment of ALS, studies have shown that NRF2 overexpression in astrocytes provided neuroprotection against mutated SOD1-induced toxicity and increased the median survival of mutant SOD1 transgenic mice (Vargas et al., 2008

When human SGECs are cultured with IL-6 for 24 to 72 hours, a downregulation of epithelial markers, an upregulation of mesenchymal markers, and a clear morphological change to a mesenchymal phenotype can be observed (56)

& Lake, R
