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This is one of the most critical points that many people overlook
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High temperatures during shipping or prolonged storage above recommended conditions can cause irreversible aggregation
Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes
