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A two-year randomized, placebo-controlled trial in 168 elderly subjects with mild cognitive impairment described the benefits of a daily regimen of 800 g of folic acid, 500 g of vitamin B 12 , and 20 mg of vitamin B 6 (177, 178)

These include oxidative stress, amyloid polypeptide toxicity, lipotoxicity, and apoptosis (20)

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Surprisingly, studies have shown the benefits of vitamin B12 injections on people suffering from weight gain and obesity issues

However, groups switched from WD to LD (WD/LD-V, WD/LD-T) tended to show greater alpha diversity compared to the control groups (WD/WD-V and LD/LD-V), which was not surprising since these animals experienced the most diet transitions with variable nutrient resources during their lifetime