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Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity

doi: 10.1158/1078-0432.CCR-05-0722

While the Cytomim system removed the HEPES buffer entirely, 18 certain energy sources, like glucose, have different impacts on reaction pH, typically due to the production of acidic byproducts

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Like most side effects of weight-loss medications, it may pass with time, but it can be a sign of more significant issues such as kidney complications