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Conversely, B12 deficiency may have an effect on metabolism that plays a role in obesity

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PLoS ONE 13(10):e0204420 Alvarez M et al (2019) Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study

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These conditions digestive conditions, such as Crohns disease and ulcerative colitis autoimmune conditions, such as celiac disease and type 1 diabetes genetic conditions, such as inherited intrinsic factor deficiency and inherited transcobalamin deficiency chronic pancreatic disease pernicious anemia vitiligo Other factors that may lead to a vitamin B12 deficiency can include drinking excessive amounts of alcohol or using certain drugs, such as some heartburn medicines and metformin