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We have previously shown that VAP-1 is expressed by HEC, in addition to smooth muscle actin (SMA) hepatic stellate cells and activated myofibroblasts in cirrhosis.12 To this effect, strong VAP-1 expression was seen in the fibrous septa and the walls of portal/septal vessels in PSC liver (see online supplementary figure 2EF)
Annu Rev Pathol 14:319338

The second major mechanism is angiogenesis: the formation of new blood vessels

These symptoms usually resolve within a day or two
