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Progress photos taken at consistent intervals will document changes that occur too gradually to notice day-to-day

Chang and his team rotate between injection sites, such as the outer thigh, upper arm, or lower abdomen, to promote healing and ensure consistent absorption

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Two further phase II trials (280, 281) with larazotide acetate failed in finding an improvement in intestinal permeability, whereas the last trial published (282) underlined possible usefulness in refractory CD, defined as malabsorption and continued villous atrophy on duodenal biopsies despite strict avoidance of gluten for a minimum of 12 months (283)