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Chitosan nanoparticles with positive charge can bind to fungal cell walls and cell membranes with negative charge, which will lead to increased permeability of cell envelopes and leakage of cytoplasmic contents from the cells, including ions and protein [66]
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Th1 cells amplify macrophage activation through IFN- (67), enhancing M1 polarization and accelerating glomerulosclerosis
