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This significantly increases the local concentration of the drug in the TME and significantly reduces off-target toxicity to normal tissues [91]

Mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) had better motor function and more dopaminergic neurons in the substantia nigra (SN) and striatum when they were given Rg1 (Jiang et al., 2015)

In addition, the expression of Pdk4 (encoding pyruvate dehydrogenase kinase-4, which is repressed by insulin and inhibits glucose oxidation) was decreased by 50% (Fig