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doi: 10.1038/cdd.2014.137 33 SeibtTMPronethBConradM

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Cognitive decline: MTHFR has been linked to dementia, Alzheimer's disease, and Parkinsons disease due to poor neurotransmitter production

However, MCT1-mediated lactate transport remains crucial for sustaining energy homeostasis and preserving tissue health in neurons and pulmonary epithelial cells under comparable conditions (195,196)

Crucially, besides inducing membrane depolarization through 7nAChR-gated Ca2+ conductance, there is growing evidence suggesting potential metabotropic activities of this ionotropic receptor [43]

F4/80: EGF-like module-containing mucin-like hormone receptor-like 1