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519 The development of selective inhibitors benefits the understanding of the roles played by different targets and their subtypes in AD, and it may also reduce the risk of side effects

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elegans model of Parkinson's Disease which expresses two pathogenic mutations in the human leucine-rich repeat kinase 2 (LRRK2) gene, loss of the glrx-10 gene has been shown to lead to an increase in the degeneration of dopaminergic neurons [135,137]
