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The primary mechanism that precipitates sepsis is inflammation (4), which generally manifests in two phases: a pro-inflammatory phase, termed systemic inflammatory response syndrome (SIRS), and an anti-inflammatory phase, designated as compensatory anti-inflammatory response syndrome (CARS) (5)

Most of the time JHR is self limited and benign, however on rare instances the reaction might be severe enough to discontinue treatment [ 6 ]

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Particularly, oxygen gradients act as critical determinants of the DDR
Stringer et al., 2008)