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As our multi-stage subtypes provide a refinement of melanoma differentiation, we built a predictive model trained on our cell line expression profiles to predict differentiation subtypes of cell lines profiled in publicly available pharmacogenomics resources (Figure 3A)

27 Inflammation Obesity associated with overnutrition induces macrophage infiltration and chronic hypoxia, causing low-grade inflammation in the adipose tissue 28 and the release of proinflammatory factors such as interleukin (IL)-1 and tumor necrosis factor (TNF-), 29,30 thus impairing insulin signaling pathway in a number of ways

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126 WaakJ.WeberS

More recently, the field of Geroscience has identified nine hallmarks of aging which are believed to contribute to aging and age-associated comorbidities (21)

Saudi J Biol Sci 28:43754383