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[5] The pathophysiology of anaphylaxis and anaphylactoid reactions stems from the effect of histamine on vascular and bronchial smooth muscle leading to cutaneous vasodilation and third-spacing (hives, rash, pruritis), bronchospasm (wheezing), and reduced systemic vascular resistance (tachycardia, hypotension)

10.1007/s10787-017-0330-7 48 MalbrainM

Exercise induces tissue hypoxia and HIF-1 redistribution in the small intestine
These same T cells are also the cause of increased skin cell production, as well as the redness and the pustular lesions

Identification of the glutaminase genes of Aspergillus sojae involved in glutamate production during soy sauce fermentation