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Side effects include myelosuppression, hepatotoxicity, fatigue, GI distress, and CNS disturbance (23,24)

doi: 10.1016/j.taap.2024.117064

Theres ongoing research in this area

24 ,

Long-term consequences of severe thiamine deficiency are manifested by the appearance of hemorrhagic and/or necrotic lesions with neuronal and dendritic spine loss in the thalamus, hypothalamus, and cerebellum (109111), as well as polyneuritis, peripheral edema, cardiac enlargement, and ophthalmoplegia ( When early, generalized thiamine deficiency is suspected, prompt administration of thiamine is advised and typically an effective treatment

A gama inclui opes com e sem estimulantes
