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Despite extensive animal data suggesting efficacy across depression, anxiety, cognitive decline, and ADHD-relevant models, not a single human clinical trial exists for any mental health application

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"The impact of coffee consumption on glutathione levels: A comprehensive review." Journal of Nutritional Biochemistry, 45(3), 234-251

In contrast, knockout experiences in mice showed that loss of GSTP1 expression leads to increased cancer susceptibility ( REGULATION OF CELLULAR ACTIVITIES THROUGH EPIGENETIC MECHANISMS Alterations in the epigenetic setup are as important as genetic aberrations and may cooperate in cancer genesis