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Alanine scanning mutagenesis revealed several residues that influence activity and specificity, including G296, Y398, and S586

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47 Pleiotropic beneficial activity based on the opposing relationship with alcohol and NSAIDs adverse effects In general cytoprotective/adaptive cytoprotection/organoprotection terms, and pleiotropic range of the beneficial activities of BPC 157, and its opposing relationship with the alcohol and NSAIDs adverse effects, already reviewed, 8 , 11 this extension is quite logical