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Mechanistically, SAC directly interacts with Keap1 to promote Nrf2 into the nucleus, enhance the transcription of antioxidant genes (such as GPX4 and NQO1), and restore the biosynthesis of GSH

Maintain an active lifestyle: Don't let joint discomfort hold you back from doing what you love

Y., Lagares, D., Tager, A

Experimental studies have utilized diverse animal models including transgenic mice (APP/PS1, 5FAD), senescence-accelerated mice (SAMP8), and even Drosophila melanogaster to explore these mechanisms

Costa et al., 2013a)

It is also expressed in the suprachiasmatic nucleus, anteroventral tegmental, preoptic, paraventricular, and nucleus accumbens within the hypothalamus (Howard et al., 1996