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Although some aberrant glycosphingolipid metabolism occurs, the disease is distinct from the Niemann-Pick Type A and B diseases, which are caused by defects in the storage of sphingomyelin in lysosomes, although there is then a secondary effect upon cholesterol storage

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Chronic meth use is also associated with: Cardiovascular strain (heart problems, high blood pressure) Severe dental problems (meth mouth) Skin issues from scratching Cognitive changes affecting memory and decision-making Mental health symptoms like chronic anxiety, paranoia, or depression For LGBTQIA+ folks, substance use patterns can be connected to experiences of minority stress, internalized stigma, discrimination in healthcare settings, or social environments where drug use is normalized (like party scenes or chemsex situations)

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