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Text Book of Biochemistry with Clinical Correlations 17 DaviesK

277 Abnormal NAD + metabolism in the pathophysiological condition Given the essential regulatory role of NAD + in fundamental physiologies, NAD + metabolic abnormalities contribute to the pathophysiology of various diseases, such as infection, cancers, metabolic diseases, aging and age-associated neurodegeneration disorders

Overexpression of proline oxidase, a p53 induced gene (PIG6) induces reactive oxygen species generation and apoptosis in cancer cells

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