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As an example, GSTZ1-1 catalyzes the cis-trans isomerization of 4-maleylacetoacetate to 4-fumarylacetoacetate within the phenylalanine catabolic pathway 21

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Elevated ROS levels are a key finding in many diseases [234] including cardiovascular and neurodegenerative diseases, cancer, diabetes mellitus, and aging [88, 89, 197, 235237]

[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Lubos E., Loscalzo J., Handy D.E

Interested individuals were initially prescreened via telephone to assess their potential eligibility based on predetermined inclusion and exclusion criteria