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Disulfiram, which was originally used as an antialcoholism drug, has been repurposed to inhibit ALDH and disrupt redox balance in CSCs, leading to increased sensitivity to chemotherapy and radiotherapy

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Concerning histone modifications, granulosa cells from PCOS patients exhibit enhanced histone deacetylase (HDAC) activity, which decreases acetylation levels of pro-inflammatory cytokines ( e.g ., TNF-, IL-6) and suppresses their transcriptional activation

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5 Research continues to explore various treatment modalities, such as exogenous melatonin, which has shown promise in improving hair follicle health and quality in animal models