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The coculture with endometrial stromal cells induced depressed cytotoxicity and aberrant metabolism of CD8+ T cells via signal transducer and activator of transcription (STAT)1/programmed cell death (PDCD)1 pathway

Glutathione (GSH) is a tripeptide, meaning it is composed of three amino acids bonded together: glutamate, cysteine, and glycine

Hayano M, Yang W, Corn C, Pagano N, Stockwell B

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A similar phenomenon has been observed in experimental models succinate accumulation activates HIF-1, further enhancing glycolysis and pro-inflammatory factor release to accelerate alveolar destruction ( 4.2.2 Key cytokines and metabolic substrate abnormalities Matrix metalloproteinases (MMP-9, MMP-12) are secreted by macrophages and neutrophils to directly degrade elastic fibers of alveolar walls