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A study on lncRNA PVT1 mechanism revealed that lncRNA PVT1 targeted miR-152, which promoted chemoresistance of OS by activating c-MET/PI3K/AKT pathway (Sun Z

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However, disruption of this equilibrium, for example through the blockage of mitochondrial fusion and fission, may lead to oxidative stress, mitochondrial dysfunction and metabolic alterations, and ultimately to the development of mitochondria-associated diseases (Xiao et al., 2021)
