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Whether declining MOTS-c is a cause or consequence of this deterioration is still being resolved, but the correlation is striking enough that some researchers have proposed plasma MOTS-c as a biomarker of mitochondrial vitality and metabolic age

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Butyrate, in particular, binds to receptors on astrocytes, suppresses neuroinflammation, enhances neurotrophic factor expression, and reduces seizure frequency in epileptic rats (Citraro et al., 2021)