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Inhibitors of NAD+ dependent histone deacetylases (sirtuins)

154,155 These opioid agonists also disrupt the endocrine system: methadone has been shown to disturb the hypothalamic pituitary gonadal axis, 156,157 and buprenorphine has not been adequately studied in respect to its long-term effects on the hypothalamic-pituitary-adrenal (HPA) axis as noted in a 2018 literature review by Varma et al

Targets collagen, elastin, and tissue remodeling mechanisms

Low secretory IgA, autoimmune conditions, or chronic illness can reduce the body's ability to keep bacterial populations in check

Nature 583 , 590595 (2020)