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Conversely, CHAC1s role in ferroptosis makes it a potential biomarker and therapeutic target, with studies indicating that its modulation could be leveraged to induce ferroptosis selectively in breast cancer cells, thereby suppressing tumor proliferation and improving patient outcomes

Evol Bioinform 12:5971 Navrot N, Collin V, Gualberto J, Gelhaye E, Hirasawa M, Rey P, Knaff DB, Issakidis E, Jacquot JP, Rouhier N (2006) Plant glutathione peroxidases are functional peroxiredoxins distributed in several subcellular compartments and regulated during biotic and abiotic stresses

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A phenomenon called augmentation where symptoms actually worsen with continued medication is a significant concern

The most frequent side-effects are gastrointestinal discomfort including nausea, abdominal pain, vomiting, and diarrhea, which range from mild to moderate (Borgna-Pignatti and Marsella, Antioxidants Vitamin E Vitamin E is the most potent biological lipophilic chain-breaking antioxidant (Stocker, 2007), actually comprising -, -, -, and -tocopherols and -, -, -, and -tocotrienols