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In addition, intestinal glutathione-S-transferase (GST) can catalyze the same reaction ( Gut microbiota-produced erucin is metabolized similarly to SFN, as shown in Figure 2

To this end, the remaining nitrogen of glutamate, which resides at the position of glutamine carbon chain (the amine group, Fig 1A), can be transferred to different ketoacids by a family of aminotransferases to produce other NEAAs, among which are alanine, aspartate, serine, and ornithine

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This also includes the gastric mucosa, where oral supplementation with PC has been shown to provide gastrointestinal support to damaged cells

AKT/mTOR acts upstream of HIF-1 [98], while evidence also shows that, in HCC, HIF-1 upregulates miR-873, which in turn activates AKT/mTOR-mediated Warburg metabolism [99]