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It has been proposed that the Cu 2+ complex at the N-terminus is reduced by electrons originating from the C-terminal methionine (Met35) residues (Huang et al., 1999[205]), resulting in the formation of the sulfide radical of Met35 (MetS + )

The HMB distinguishes itself from methionine due to the presence of a hydroxyl group on the alpha carbon, in contrast to methionines amino group (Dibner, 2003)

96 MiglioreC.GiordanoS

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466 It is often used to analyze the mechanisms underlying disease occurrence and progression and the effects of small-molecule compounds

PMID: 29355075