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Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology Virulence 7 4: 387-94
As an aging man develops osteoporosis, excess calcium released into the blood contributes to arterial calcification (Faloon 2009)
Higgins JPT, Green S (editors)

Thats why they must be provided through the diet
