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Sequentially, Vit-C-mediated restoration of TET, also when mutated, enables the re-expression of tumour-suppressor genes in cancer cells [2, 3, 105, 174]

This reflects a key implication in malignancies, whose intrinsic environment is highly dependent on glycolysis, as characterized by the Warburg effect

Lactate catabolism facilitates glycolysis, but citrate catabolism is mostly finished in the first or second week of ripening

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

Silverman MA, Konnikova L, Gerber JS

10.1158/2159-8290.Cd-19-0338 43 LayJ