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Tingling sensations or numbness in extremities may occur if pyridoxine is taken in very high doses, potentially affecting nerve function adversely

Research goals: Longevity & Anti-Aging, Metabolic & Weight Description 5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that converts nicotinamide and S-adenosyl-l-methionine (SAM) into 1-methylnicotinamide and S-adenosyl-l-homocysteine

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AOD-9604 is a modified version of this fragment, designed to enhance stability and activity in fat metabolism

This requires that the molecule be chemically modified without altering its therapeutic action, which is not always possible and needs to be optimised for each individual molecule