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The majority of participants were clinically obese adults, though one trial included healthy non-obese volunteers

For blood pressure specifically, this nitric oxide modulation could translate to improved vascular compliance, meaning blood vessels that expand and contract more readily in response to changing demands

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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

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