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Shift the site each week (at least 1 inch over) to prevent lipohypertrophy [15]

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We used four criteria for estimation of the edema: a pale myelin, sieve-like appearance of myelinated areas, dilation of perivascular and pericellular spaces and vacuolar appearance of the neuropil of gray matter

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This raises questions about how their interaction landscapes might overlap, intersect, or even potentiate each others impacts within research models