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Initially identified as nine fundamental biological drivers of aging (13), the list has been updated to include twelve hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis (14)

In this review, we discuss the origin of macrophages within plaques, their phenotypic diversity, metabolic shifts, and fate and the roles they play in the dynamic progression of atherosclerosis

Sato R, da Fonseca GWP, das, Neves W, von Haehling S

Be extremely careful around eyes

Applying for a new Notice of Intent Renewing a Notice of Intent 3

Moderate ulcerative colitis responds quickly to appropriate therapies