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Prevalence and Predictors of Premature Graying of Hair Before the Age of 30: A Cross-Sectional Study in Saudi Arabia

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A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data

doi: 10.1186/2193-1801-2-218

The study found no difference in 24-hour postoperative morphine consumption (both groups ~24 mg) or in pain scores, side effects, length of stay, or functional outcomes up to 6 months