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Moreover, the process was scalable to up to 2500 L, but the production costs were high compared with the fed-batch operated process, despite the lower productivity attained (about 75% lower, 99% conversion) [84]

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SA--Gal is widely utilized as a senescence marker in aging research 51,52,53 , and has also been previously evaluated in HEI-OC1 cells 2,54

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