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Nonetheless, more research needs to be done to elucidate NP interactions with the diverse regions of the brain and the ways in which these cell-cell interactions change under disease conditions, especially with the increasingly detailed maps of brain cell functions and interactions that are now available

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As a supplementary estimand, we will also perform a dose-response analysis in all participants who provide a blood sample within the required time period (regardless of medication compliance) 2
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Simpson EL, Silverberg JI, Worm M, et al

The synthesis method of the Cagrilintide comprises the third step of preparing 200mL of cracking reagent, adding the full-protection peptide under an ice bath condition, returning to room temperature after 0.5h, continuing to react for 2h, adding anhydrous ether for precipitation after the reaction is finished, performing centrifugal precipitation for multiple times, adding 300mL of ether each time, and drying to obtain the Cagrilintide product
