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Some portion of intranasally administered peptides may reach the brain through the olfactory pathway, bypassing the blood-brain barrier that limits systemic delivery to CNS tissues

The Food and Nutrition Board, the National Academy of Sciences-National Research Council recommend that lactating women should consume 4 mcg of vitamin B12 daily (11)

however, intranasal therapy should only be instituted for maintenance treatment after control of the condition has been obtained by the parenteral route

These risks are exactly why an intramuscular injection is safer given by a trained clinician than self-administered at home

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