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The impaired catabolism of BCAAs and downregulated BCAA metabolism gene sets in liver tissues have been shown in the pathogenesis of NAFLD and NASH [145, 146]

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3234 In one paper, authors found increased 28-day mortality in children for those with hyperammonemia with either liver failure (8-fold increase) or urea cycle disorders (5-fold increase) with levels above 280 g/dL

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