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Building on these findings, studies have shown that the active mitochondrial network in CRC cells exerts a physical metabolic occupancy effect that impedes immunological synapse formation, while the associated release of ROS further suppresses immune cell function

10.1016/B978-0-12-420117-0.00008-6 102

To translate these advances, modified proteins have been functionally expressed in heterologous systems such as Escherichia coli Origami (DE3) (Castro-Martnez et al., 2012)

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Fadok et al , 1998

DNA Demethylation by 5-Aza-2-Deoxycytidine Is Imprinted, Targeted to Euchromatin, and Has Limited Transcriptional Consequences