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Experimental models of bone defects have shown that, when SVVYGLR was implanted together with a collagen sponge, an upregulation of osteogenesis and angiogenesis was observed [169, 239]

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Furthermore, circulating aged neutrophils (CANs), a subset of neutrophils with high surface expression of CXCR4 and low CD62L and participate in the VOC process, are also higher in SCD [37, 45, 49]